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Product Name LSR/Lipolysis Stimulated Lipoprotein Receptor Chinese Name 脂肪分解刺激Lipoprotein受体抗体 Alias ILDR3; Immunoglobulin like domain containing receptor 3; Lipolysis stimulated remnant; Lipolysis-stimulated lipoprotein receptor; LISCH; LISCH protein; LISCH7; Liver specific bHLH Zip transcription factor; LSR; LSR_HUMAN; MGC10659; MGC48312; MGC48503. Research Area Tumour Cell biology Signal transduction The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 71kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human LSR/Lipolysis Stimulated Lipoprotein Receptor: 121-220/649 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail LSR is a 649 amino acid single-pass membrane protein that contains one immunoglobulin-like domain and localizes to the cell membrane. Existing as a homotrimer or a homotetramer, LSR is thought to play a role in the clearing of triglyceride-rich lipoproteins from blood, specifically via binding to low density lipoproteins (LDLs) and very low density lipoproteins (VLDLs) and facilitating their uptake into cells. Overexpression of LSR may be associated with increased colon tumor growth, suggesting an involvement for LSR in tumor formation and metastasis. Multiple isoforms of LSR exist due to alternative splicing events. The gene encoding LSR maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes.
Function:
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells.
Subcellular Location:
Cell membrane.
Similarity:
Belongs to the immunoglobulin superfamily. LISCH7 family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SWISS:
Q86X29
Gene ID:
51599
Database links:Entrez Gene: 51599 Human
SwissProt: Q86X29 Human
Unigene: 466507 Human
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