Product Name	IL-11
Chinese Name	白介素11抗体
Alias	Interleukin-11; Adipogenesis inhibitory factor; AGIF; IL 11; IL11; Interleukin 11; Oprelvekin; IL11_HUMAN.
literatures	Specific References  (2)     |     SL1827R has been referenced in 2 publications. [IF=5.555] Pengsen Wu. et al. IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy. Front Endocrinol. 2022; 13: 846106  IHC ;  Human.   PubMed:35273577 [IF=2.376] Lifei Li. et al. GnRH agonist treatment regulates IL-6 and IL-11 expression in endometrial stromal cells for patients with HRT regiment in frozen embryo transfer cycles. Reprod Biol. 2022 Jun;22:100608  WB ;  Human.   PubMed:35151984
Research Area	Cardiovascular  Cell biology  immunology  Neurobiology  Stem cells  vascular endothelial cell  lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	19kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-11: 22-120/199
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Interleukin 11 is a pleiotropic cytokine produced by mesenchymal-derived adherent cells. IL11 shares many functions of IL6 and LIF, including potentiation of megakaryocyte activity, enhancement of human myeloma cell proliferation, and enhancement of hepatic acute phase protein production. Interleukin 11 directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, and induces megakaryocyte maturation resulting in increased platelet production. Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy. Function: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Subcellular Location: Secreted. Similarity: Belongs to the IL-6 superfamily. SWISS: P20809 Gene ID: 3589 Database links: Entrez Gene: 3589 Human Omim: 147681 Human SwissProt: P20809 Human Unigene: 467304 Human 白介素11，是一种多向性cell factor。很多细胞都能合成IL11，如：endothelial cells、纤维母细胞、软骨细胞、滑膜细胞、成骨细胞、epithelial cells、神经元、胸腺等。正常的血清中，IL11表达很少或处在检测水平之下。对造血系统的功能包括：Stem cells、巨核细胞、marrow cells、红细胞和Blymphocyte的增生和发育。对造血系统之外也具有多相性的作用，有些是刺激和促进增生，有些是抑制作用。人、大鼠、小鼠的IL-11的前体有199个氨基酸。成熟形态为178个氨基酸。
Product Picture	Sample: Testis (Mouse) Lysate at 30 ug Primary: Anti- IL-11 (SL1827R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/10000 dilution Predicted band size: 19 kD Observed band size: 19 kD Sample: Lane 1: Mouse Kidney tissue lysates Lane 2: Rat Kidney tissue lysates Primary: Anti-IL-11 (SL1827R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 19 kDa Observed band size: 19 kDa Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (IL-11) Polyclonal Antibody, Unconjugated (SL1827R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining. Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (IL-11) Polyclonal Antibody, Unconjugated (SL1827R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.

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