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Product Name LIM2 Chinese Name 晶状体纤维膜内在蛋白抗体 Alias Lens fiber membrane intrinsic protein; Lens intrinsic membrane protein 2 19kDa; Lens intrinsic membrane protein 2; LIM 2; Lim2; LMIP_HUMAN; MP17; MP18; MP19; MP20; To3. Research Area Cell biology immunology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Horse, Rabbit, ) Applications WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 19kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human LIM2: 1-100/173 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes an eye lens-specific protein found at the junctions of lens fiber cells, where it may contribute to cell junctional organization. It acts as a receptor for calmodulin, and may play an important role in both lens development and cataractogenesis. Mutations in this gene have been associated with cataract formation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Function:
Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.
Subcellular Location:
Membrane.
Tissue Specificity:
Eye lens specific.
Similarity:
Belongs to the PMP-22/EMP/MP20 family.
SWISS:
P55344
Gene ID:
3982
Database links:Entrez Gene: 3982 Human
Omim: 154045 Human
SwissProt: P55344 Human
Unigene: 162754 Human
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