Product Name	MCM8
Chinese Name	微小染色体维持缺陷蛋白8抗体
Alias	C20orf154; dJ967N21.5; DNA helicase MCM8; DNA replication licensing factor MCM8; MCM8; MCM8_HUMAN; MGC119522; MGC119523; MGC12866; MGC4816; Minichromosome maintenance 8; Minichromosome maintenance complex component 8; REC.
Research Area	Cell biology  Signal transduction  transcriptional regulatory factor  Binding protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	93kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MCM8: 301-400/840
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013] Function: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle. Subcellular Location: Nucleus. Localizes to nuclear foci and colocalizes with RAD51. Tissue Specificity: Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers. Similarity: Belongs to the MCM family. Contains 1 MCM domain. SWISS: Q9UJA3 Gene ID: 84515 Database links: Entrez Gene: 421314 Chicken Entrez Gene: 507507 Cow Entrez Gene: 477163 Dog Entrez Gene: 100065561 Horse Entrez Gene: 84515 Human Entrez Gene: 66634 Mouse Entrez Gene: 296178 Rat Omim: 608187 Human SwissProt: Q9UJA3 Human SwissProt: Q9CWV1 Mouse SwissProt: D3ZVK1 Rat Unigene: 597484 Human Unigene: 157070 Mouse Unigene: 70183 Rat

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