Product Name	IOC4
Chinese Name	IOC4
Alias	Hypothetical 55.4 kDa protein in MCM1-NUP116 intergenic region; Ioc4p; IOC4_YEAST; YMR044W.
Research Area	Cell biology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	55kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Saccharomyces cerevisiae IOC4: 401-475/475
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	IOC4 is a member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing. IOC4 contains a PWWP motif. Function: Functions as component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing. Subunit: Component of the ISW1B complex, which at least consists of ISW1, IOC2 and IOC4. Subcellular Location: Nuclear SWISS: Q04213 Gene ID: 855061 Database links: Entrez Gene: 855061 Saccharomyces cerevisiae SwissProt: Q04213 Saccharomyces cerevisiae

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