Product Name	ITSN1
Chinese Name	交叉蛋白1抗体
Alias	Intersectin-1; Intersectin 1; Intersectin1; ITSN 1; ITSN; ITSN1_HUMAN; Human intersectin SH3 domain containing protein SH3P17; Intersectin 1 SH3 domain protein; intersectin 1 short form variant 3; intersectin 1 short form variant, 11; Intersectin short form; intersectin short variant 12; MGC134948; MGC134949; SH3 domain containing protein 1A; SH3 domain protein 1A; SH3 domain-containing protein 1A; SH3D1A; SH3P17; Src homology 3 domain containing protein.
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	195kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ITSN1: 1001-1100/1721
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008] Function: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1. Subcellular Location: Endomembrane system. Cell junction > synapse > synaptosome. Cell projection > lamellipodium. Tissue Specificity: Isoform 2 is ubiquitous in adult and fetal tissues with high expression in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested and low expression in thymus, blood, lung, liver and pancreas. Isoform 1 is expressed almost exclusively in the brain, in all brain regions. Not expressed in the spinal cord. Similarity: Contains 1 C2 domain. Contains 1 DH (DBL-homology) domain. Contains 2 EF-hand domains. Contains 2 EH domains. Contains 1 PH domain. Contains 5 SH3 domains. SWISS: Q15811 Gene ID: 602442 Database links: Entrez Gene: 6453 Human Entrez Gene: 16443 Mouse Entrez Gene: 29491 Rat Omim: 602442 Human SwissProt: Q15811 Human SwissProt: Q9Z0R4 Mouse SwissProt: Q9WVE9 Rat Unigene: 160324 Human Unigene: 40546 Mouse Unigene: 48657 Rat

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