Product Name	Tollip
Chinese Name	Toll蛋白相互作用蛋白抗体
Alias	Adapter protein; FLJ33531; IL 1RAcPIP; IL1RAcPIP; TOLIP; TOLIP_HUMAN; Toll interacting protein; Toll-interacting protein; tollip.
Research Area	Cell biology  immunology  Signal transduction  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	30kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Tollip: 101-200/274
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011] Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products. Similarity: Belongs to the tollip family. Contains 1 C2 domain. Contains 1 CUE domain. SWISS: Q9H0E2 Gene ID: 54472 Database links: Entrez Gene: 54472 Human Entrez Gene: 423099 Chicken Entrez Gene: 539480 Cow Entrez Gene: 54473 Mouse Entrez Gene: 361677 Rat Entrez Gene: 336876 Zebrafish Omim: 606277 Human SwissProt: Q5ZK05 Chicken SwissProt: Q2LGB5 Cow SwissProt: Q9H0E2 Human SwissProt: Q9QZ06 Mouse SwissProt: A2RUW1 Rat SwissProt: Q7ZV43 Zebrafish Unigene: 368527 Human Unigene: 103551 Mouse Unigene: 137040 Rat Unigene: 79855 Zebrafish
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Tollip) Polyclonal Antibody, Unconjugated (SL18168R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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