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Product Name TNRC5/PRAT4A Chinese Name Toll样受体4相关蛋白抗体 Alias CAG repeat containing; CAG4A; Canopy 3 homolog; cnpy3; CNPY3_HUMAN; CTG repeat protein 4a; ERDA 5; ERDA5; Expanded repeat domain CAG/CTG 5; Expanded repeat-domain protein CAG/CTG 5; OTTHUMP00000016408; PRAT4A; Protein associated with Tlr4; Protein associated with Toll like receptor 4A; Protein canopy homolog 3; TNRC 5; Trinucleotide repeat containing 5; Trinucleotide repeat-containing gene 5 protein. Research Area Cell biology immunology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 31kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TNRC5/PRAT4A: 61-160/278 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail PRAT4A is associated with the immature form of TLR4 (MIM 603030) and regulates its cell surface expression (Wakabayashi et al., 2006 [PubMed 16849487]).[supplied by OMIM, Mar 2008]
Function:
Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptative immune responses.
Subcellular Location:
Endoplasmic reticulum.
Similarity:
Belongs to the canopy family.
Contains 1 saposin B-type domain.
SWISS:
Q9BT09
Gene ID:
10695
Database links:Entrez Gene: 10695 Human
Omim: 610774 Human
SwissProt: Q9BT09 Human
Unigene: 414099 Human
Unigene: 43984 Rat
Product Picture Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PRAT4A) Polyclonal Antibody, Unconjugated (SL18160R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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