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Product Name HUCE1 Chinese Name 脑蛋白1抗体 Alias Cerebral protein 1; hypothetical protein LOC23378; KIAA0409; Nucleomethylin; Ribosomal RNA processing 8 methyltransferase homolog; Ribosomal RNA processing 8, methyltransferase, homolog (yeast); Ribosomal RNA processing protein 8; Ribosomal RNA-processing protein 8; RRP 8; RRP8; RRP8 methyltransferase homolog; RRP8_HUMAN. Research Area Cell biology Neurobiology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 51kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HUCE1: 131-230/456 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Subcellular Location:
Nucleus > nucleolus. Localizes at rDNA locus.
Similarity:
Belongs to the methyltransferase superfamily. RRP8 family.
SWISS:
O43159
Gene ID:
23378
Database links:Entrez Gene: 23378 Human
Entrez Gene: 100070052 Horse
Entrez Gene: 101867 Mouse
Entrez Gene: 100355346 Rabbit
SwissProt: O43159 Human
SwissProt: Q9DB85 Mouse
Unigene: 652255 Human
Unigene: 231400 Mouse
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