Product Name	HSPC210/GSK3beta interaction protein
Chinese Name	GSK3β相互作用蛋白抗体
Alias	C14ORF129; Chromosome 14 open reading frame 129; GSK3-beta interaction protein; GSK3beta interaction protein; GSKIP; GSKIP; GSKIP_HUMAN; MGC4945; UPF0279.
Research Area	Cell biology  immunology  Signal transduction  Cyclin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	16kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GSKIP : 1-100/139
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012] Subcellular Location: Cytoplasm. Tissue Specificity: Detected in heart, brain, placenta, liver, skeletal muscle, kidney, testis, lung and pancreas. Similarity: Belongs to the UPF0279 family. SWISS: Q9P0R6 Gene ID: 51527 Database links: Entrez Gene: 51527 Human Entrez Gene: 66787 Mouse Entrez Gene: 362778 Rat SwissProt: Q9P0R6 Human SwissProt: Q8BGR8 Mouse SwissProt: Q5PPI3 Rat Unigene: 728153 Human Unigene: 248019 Mouse Unigene: 3701 Rat

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