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Rabbit Anti-Contactin 6 antibody
Rabbit Anti-Contactin 6 antibody
CNTN 6; CNTN6; CNTN6_HUMAN; Contactin 6 precursor; Contactin-6; Contactin6; hNB 3; hNB-3; hNB3; MGC133256; NB 3; NB3; Neural adhesion molecule; Neural recognition molecule NB 3; Neural recognition molecule NB-3.
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  • NO.:SL1797R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Rat,(predicted: Human,Mouse,Dog,Pig,Cow,Horse,Sheep,)
    Applications:ELISA IHC-P IHC-F IF
    concentration:1mg/ml
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Details

Product Name Contactin 6
Chinese Name 神经细胞NB3特定蛋白抗体
Alias CNTN 6; CNTN6; CNTN6_HUMAN; Contactin 6 precursor; Contactin-6; Contactin6; hNB 3; hNB-3; hNB3; MGC133256; NB 3; NB3; Neural adhesion molecule; Neural recognition molecule NB 3; Neural recognition molecule NB-3.  
Research Area Neurobiology  The cell membrane蛋白  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Sheep, )
Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 109kDa
Cellular localization The cell membrane 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human NB3: 85-200/1028 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail Contactin 6 is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein which functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system.

Function:
Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination.

Subunit:
Belongs to the immunoglobulin superfamily. Contactin family. Contains 4 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor (By similarity).

Tissue Specificity:
Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.

Similarity:
Belongs to the immunoglobulin superfamily. Contactin family.
Contains 4 fibronectin type-III domains.
Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
Q9UQ52

Gene ID:
27255

Database links:

Entrez Gene: 27255 Human

Entrez Gene: 53870 Mouse

Entrez Gene: 27256 Rat

Omim: 607220 Human

SwissProt: Q9UQ52 Human

SwissProt: Q9JMB8 Mouse

SwissProt: P97528 Rat

Unigene: 387300 Human

Unigene: 321671 Mouse

Unigene: 10644 Rat



Product Picture
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Contactin 6) Polyclonal Antibody, Unconjugated (SL1797R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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