Product Name	GDF9
Chinese Name	生长分化因子9抗体
Alias	GDF9; GDF-9; GDF 9; GDF9_HUMAN; Growth differentiation factor 9.
literatures	Specific References  (2)     |     SL1795R has been referenced in 2 publications. [IF=2.81] Zhang et al. Simulated Microgravity Using a Rotary Culture System Compromises the In Vitro Development of Mouse Preantral Follicles. (2016) PLoS.On. 11:e0151062  IHC-P ;  Mouse.   PubMed:26963099 [IF=2.586] Gökçe Nur Arık. et al. Melatonin effective to reduce the microscopic symptoms of polycystic ovary syndrome-related infertility: An experimental study. TISSUE CELL. 2023 Jan;:102015  IHC,WB ;  Rat.   PubMed:36657254
Research Area	Cardiovascular  immunology  Signal transduction  Stem cells  Growth factors and hormones  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	15kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GDF-9: 351-452/452
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-beta superfamily. [provided by RefSeq, Jul 2008] Function: Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. Subunit: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked (By similarity). Subcellular Location: Secreted (By similarity). Tissue Specificity: Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level). Post-translational modifications: Phosphorylated; phosphorylation is critical for GDF9 function. In vitro, can be phosphorylated by CK at Ser-325. DISEASE: Note=Altered GDF9 function may be involved in ovarian disorders. Rare variants in GDF9 have been found in patients with premature ovarian failure and mothers of dizygotic twins. Similarity: Belongs to the TGF-beta family. SWISS: O60383 Gene ID: 2661 Database links: Entrez Gene: 2661 Human GenBank: NP_005251 Human Omim: 601918 Human SwissProt: O60383 Human SwissProt: Q4VAW5 Human Unigene: 25022 Human GDF9属于转移生长因子–β(TGF-β)及骨形态发生蛋白（BMP）家族成员。

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