Product Name	MSRB2
Chinese Name	蛋氨酸亚砜还原酶B2抗体
Alias	CBS 1; CBS1; CGI 131; Methionine sulfoxide reductase B2; Methionine-R-sulfoxide reductase B2; MGC26104; mitochondrial; MSRB 2; MSRB; Msrb2; MSRB2_HUMAN; PILB; Pilin like transcription factor.
literatures	Specific References  (1)     |     SL17861R has been referenced in 1 publications. [IF=2.639] Gaolong Zhong. et al. Effects of Long-Term Exposure to Copper on the Keap1/Nrf2 Signaling Pathway and Msr-Related Redox Status in the Kidneys of Rats. 2021 Jan 22  IF ;  Rat.   PubMed:33479888
Research Area	Tumour  Cell biology  immunology  Signal transduction  The new supersedes the old  Mitochondrion
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Dog, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	20kDa
Cellular localization	cytoplasmic Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MSRB2: 31-130/182
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Methionine is one of the most readily oxidized essential amino acids and an intermediate in the biosynthesis of cysteine, carnitine, taurine, lecithin, phosphatidylcholine and other phospholipids. In its oxidative state, Methionine is regulated in vivo by methionine sulfoxide reductases (Msr). MsrB2 is a 182 amino acid mitochondrial protein that is ubiquitously expressed. Belonging to the MsrB Met sulfoxide reductase family, MsrB2 acts as a catalyst for the reduction of free and protein-bound methionine sulfoxide to methionine. Upon oxidative stress, MsrB2 is suggested to play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. MsrB2 utilizes zinc ions, one per subunit, as cofactors. Function: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. Subcellular Location: Mitochondrion. Tissue Specificity: Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate. Similarity: Belongs to the MsrB Met sulfoxide reductase family. SWISS: Q9Y3D2 Gene ID: 22921 Database links: Entrez Gene: 22921 Human Entrez Gene: 361286 Rat Omim: 613782 Human SwissProt: Q9Y3D2 Human SwissProt: Q4FZX5 Rat Unigene: 461420 Human Unigene: 23802 Rat
Product Picture	Tissue/cell: mouse embryo tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-MSRB2 Polyclonal Antibody, Unconjugated(SL17861R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-MSRB2 Polyclonal Antibody, Unconjugated(SL17861R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Paraformaldehyde-fixed, paraffin embedded (mouse kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MSRB2) Polyclonal Antibody, Unconjugated (SL17861R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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