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Rabbit Anti-MRM1 antibody
Rabbit Anti-MRM1 antibody
A530065E19Rik; ENSMUSG00000054212; FLJ22578; Mitochondrial large ribosomal RNA ribose methylase; Mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae); MRM1; MRM1_HUMAN; OTTMUSP00000008034; RGD1566232; RP23-293L24.6; rRNA methyltransferase 1, mit
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  • NO.:SL17763R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Dog,Horse,Rabbit,Sheep,)
    Applications:ELISA IHC-P IHC-F ICC IF
    concentration:1mg/ml
  • Goods click count:24
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Details

Product Name MRM1
Chinese Name MitochondrionrRNA甲基转移酶1抗体
Alias A530065E19Rik; ENSMUSG00000054212; FLJ22578; Mitochondrial large ribosomal RNA ribose methylase; Mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae); MRM1; MRM1_HUMAN; OTTMUSP00000008034; RGD1566232; RP23-293L24.6; rRNA methyltransferase 1, mitochondrial.  
Research Area Cell biology  transcriptional regulatory factor  Mitochondrion  Epigenetics  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep, )
Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 36kDa
Cellular localization cytoplasmic Mitochondrion
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human MRM1: 231-330/353 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail MRM1 is a 353 amino acid protein that localizes to the mitochondrion and belongs to the RNA methyltransferase trmH family. Expressed as two alternatively spliced isoforms, MRM1 specifically methylates the ribose of guanosine G-2270 in the peptidyl transferase center of the mitochondrial large ribosomal RNA (21S). The gene encoding MRM1 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Function:
Probably methylates the ribose of guanosine G-2270 in the peptidyl transferase center of the mitochondrial large ribosomal RNA (21S).

Subcellular Location:
Mitochondrion.

Similarity:
Belongs to the RNA methyltransferase TrmH family.

SWISS:
Q6IN84

Gene ID:
79922

Database links:

Entrez Gene: 79922 Human

Entrez Gene: 217038 Mouse

Entrez Gene: 363661 Rat

SwissProt: Q6IN84 Human

SwissProt: Q99J25 Mouse

Unigene: 194864 Human

Unigene: 280825 Mouse

Unigene: 43486 Rat



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