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Product Name MRM1 Chinese Name MitochondrionrRNA甲基转移酶1抗体 Alias A530065E19Rik; ENSMUSG00000054212; FLJ22578; Mitochondrial large ribosomal RNA ribose methylase; Mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae); MRM1; MRM1_HUMAN; OTTMUSP00000008034; RGD1566232; RP23-293L24.6; rRNA methyltransferase 1, mitochondrial. Research Area Cell biology transcriptional regulatory factor Mitochondrion Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 36kDa Cellular localization cytoplasmic Mitochondrion Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MRM1: 231-330/353 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail MRM1 is a 353 amino acid protein that localizes to the mitochondrion and belongs to the RNA methyltransferase trmH family. Expressed as two alternatively spliced isoforms, MRM1 specifically methylates the ribose of guanosine G-2270 in the peptidyl transferase center of the mitochondrial large ribosomal RNA (21S). The gene encoding MRM1 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Function:
Probably methylates the ribose of guanosine G-2270 in the peptidyl transferase center of the mitochondrial large ribosomal RNA (21S).
Subcellular Location:
Mitochondrion.
Similarity:
Belongs to the RNA methyltransferase TrmH family.
SWISS:
Q6IN84
Gene ID:
79922
Database links:Entrez Gene: 79922 Human
Entrez Gene: 217038 Mouse
SwissProt: Q6IN84 Human
SwissProt: Q99J25 Mouse
Unigene: 194864 Human
Unigene: 280825 Mouse
Unigene: 43486 Rat
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