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Product Name MOCS2 Chinese Name 钼辅因子合成蛋白2抗体 Alias MCBPE; MOCO1; MOCO1 B; MOCO1B; MOCS 2; MOCS2; MOCS2A; MOCS2B; Molybdenum cofactor biosynthesis protein E; Molybdenum cofactor synthesis 2; Molybdenum cofactor synthesis protein 2 large subunit; molybdenum cofactor synthesis protein 2 small subunit; molybdenum cofactor synthesis protein 2A; Molybdenum cofactor synthesis protein 2B; Molybdopterin synthase; Molybdopterin synthase large subunit; molybdopterin-synthase small subunit; MPT synthase; MPTS; OTTHUMP00000122459; sulfur carrier protein MOCS2A. Research Area Cell biology Signal transduction The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 21kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MOCS2: 51-150/188 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]
Function:
The large (MOCS2B) and small (MOCS2A) subunits of molybdopterin synthase are both encoded from the MOCS2 gene by overlapping open reading frames. MOCS2B is the catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. It acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
Subunit:
Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Highest levels are found in heart and skeletal muscle. Lower levels are present in brain, kidney and pancreas.Very low levels are found in lung and peripheral blood leukocytes.
DISEASE:
Molybdenum cofactor deficiency, complementation group B(MOCODB)
Similarity:
Belongs to the MoaE family. MOCS2B subfamily.
SWISS:
O96007
Gene ID:
4338
Database links:Entrez Gene: 4338 Human
Omim: 603708 Human
SwissProt: O96007 Human
Unigene: 163645 Human
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