Product Name	SPATA20
Chinese Name	精子发生相关蛋白20抗体
Alias	SPATA20; Sperm protein SSP411; Sperm-specific protein 411; Spermatogenesis associated 20; Spermatogenesis-associated protein 20; SPT20_HUMAN; Ssp411; Tisp78; Transcript increased in spermiogenesis 78.
Research Area	Cell biology  Developmental biology  Stem cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	58kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SPATA20: 431-530/786
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SPATA20 is a 786 amino acid protein that may be involved in fertility regulation. SPATA20 is expressed in testis in an age dependent manner and localizes to round and elongated spermatids. SPATA20 contains a conserved thioredoxin-like domain near the N-terminus region and exists as four isoforms produced by alternative splicing events. SPATA20 is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Function: May play a role in fertility regulation. Subcellular Location: Secreted. SWISS: Q8TB22 Gene ID: 64847 Database links: Entrez Gene: 511363 Cow Entrez Gene: 491082 Dog Entrez Gene: 100714104 Guinea pig Entrez Gene: 100069987 Horse Entrez Gene: 64847 Human Entrez Gene: 217116 Mouse Entrez Gene: 100286812 Pig Entrez Gene: 360604 Rat Omim: 613939 Human SwissProt: Q8TB22 Human SwissProt: Q80YT5 Mouse SwissProt: Q6T393 Rat Unigene: 103147 Human

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