Product Name	CCL22
Chinese Name	嗜酸粒细胞趋化蛋白22抗体
Alias	CCL22; DC/B-CK; A-152E5.1; ABCD 1; ABCD-1; ABCD1; CC chemokine STCP-1; ccl 22; MGC34554; SCYA22; small inducible cytokine subfamily A (Cys-Cys) member 22; STCP 1; STCP-1; MDC; stimulated T cell chemotactic protein 1; CCL22_Mouse; C-C motif chemokine 22; MDC(1-69); Macrophage-derived chemokine; Small-inducible cytokine A22; Stimulated T-cell chemotactic protein 1; MDC(3-69); MDC(5-69); MDC(7-69); CCL22_HUMAN.
literatures	Specific References  (3)     |     SL1761R has been referenced in 3 publications. [IF=9.473] Wupeng Liao. et al. Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function. BRIT J PHARMACOL. 2022 Nov;:  IHC ;  Mouse.   PubMed:36440573 [IF=3.361] Hou DD et al. Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis. Int Immunopharmacol. 2019 Jun 7;74:105676.  IHC-P ;  Mouse.   PubMed:31181406 [IF=3.322] Shumin Bi. et al. miR-210 promotes hepatocellular carcinoma progression by modulating macrophage autophagy through PI3K/AKT/mTOR signaling. BIOCHEM BIOPH RES CO. 2023 Apr;:  IF ;  Human.   PubMed:37099810
Research Area	Tumour  Cell biology  immunology  Signal transduction  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	10kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse C-C motif chemokine 22: 51-93/93
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq]. Function: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. Subcellular Location: Secreted. Tissue Specificity: Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis. Similarity: Belongs to the intercrine beta (chemokine CC) family. SWISS: O88430 Gene ID: 20299 Database links: Entrez Gene: 20299 Mouse Entrez Gene: 117551 Rat SwissProt: O88430 Mouse Unigene: 12895 Mouse Unigene: 48727 Rat

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