Product Name	SPAG11B
Chinese Name	精子相关抗原11B抗体
Alias	EP2; EP2C; EP2D; Epididymal protein 2; HE2; HE2C; Protein EP2; SPAG11; Sperm antigen HE2; Sperm associated antigen 11; Sperm associated antigen 11B.
Research Area	Cell biology  Developmental biology  Cell type markers
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	9kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SPAG11B: 41-103/103
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SPAG11B is a 103 amino acid precursor protein that exists as four alternatively spliced isoforms, designated EP2A, EP2B, EP2C and EP2D, all of which are androgen-dependent, epididymis-specific secretory proteins that may play a role in sperm maturation and overall function. The gene encoding the SPAG11B precursor maps to a region on chromosome 8 that is near the ∫-defensin gene cluster and it is suggested that SPAG11B may exhibit functional characteristics (such as antimicrobial activity) that are similar to ∫-defensins. Human chromosome 8, on which the SPAG11B gene is localized, consists of nearly 146 million base pairs and houses more than 800 genes, some of which are associated with a variety of diseases and malignancies. Function: SPAG11B belongs to the SPAG11 family. The specific function of SPAG11B has not been determined, but it is thought to be involved in sperm maturation. It is specifically expressed in caput and proximal corpus of epididymis and is present in the epididymal epithelium and on the sperm surface, with a subacrosomal equatorial distribution on the sperm head. There are two named isoforms. Subcellular Location: Secreted Tissue Specificity: Specifically expressed in caput and proximal corpus of epididymis. Present in the epididymal epithelium and on the sperm surface, with a subacrosomal equatorial distribution on the sperm head. Similarity: Belongs to the SPAG11 family. SWISS: Q08648 Gene ID: 10407 Database links: Entrez Gene: 10407 Human SwissProt: Q08648 Human

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