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Rabbit Anti-CCDC49 antibody
Rabbit Anti-CCDC49 antibody
Coiled-coil domain-containing protein 49; CWC25_HUMAN; Pre-mRNA-splicing factor CWC25 homolog.
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  • NO.:SL17611R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Pig,Cow,Horse,Rabbit,Sheep,)
    Applications:ELISA IHC-P IHC-F ICC IF
    concentration:1mg/ml
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Details

Product Name CCDC49
Chinese Name 卷曲螺旋结构域蛋白49抗体
Alias Coiled-coil domain-containing protein 49; CWC25_HUMAN; Pre-mRNA-splicing factor CWC25 homolog.  
Research Area Cell biology  Signal transduction  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 50kDa
Cellular localization The cell membrane 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human CCDC49: 351-425/425 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail Spliceosomes are large ribonucleoproteins that remove introns from nuclear pre-mRNA in a two-step reaction. CCDC49 is a 425 amino acid protein that is involved in the catalytic steps of splicing in Saccharomyces cerevisiae. CCDC49 associates with a component of the Prp19-associated complex, CEF1, which is involved in spliceosome activation. It is likely that CCDC49 facilitates juxtaposition of the 5’ splice site and branch point during the final step in the first catalytic reaction. There are two isoforms of CCDC49 that are produced as a result of alternative splicing events.

Similarity:
Belongs to the CWC25 family.

SWISS:
Q6ZUS6

Gene ID:
91050

Database links:

Entrez Gene: 613278 Cow

Entrez Gene: 91050 Human

Entrez Gene: 100503884 Mouse

Entrez Gene: 688939 Rat

SwissProt: Q0VCP9 Cow

SwissProt: Q6ZUS6 Human

Unigene: 106432 Human

Unigene: 332379 Mouse



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