Product Name	Met Enkephalin
Chinese Name	甲硫氨酸脑啡肽抗体
Alias	Met-enkephalin; [Met]enkephalin; Enkephalin; M-ENK; Methionine Enkephalin; OGF; Opioid growth factor; PENK; PPA; Proenkephalin A; Proenkephalin; M enk; PE; PENK-A; PENK_HUMAN.
literatures	Specific References  (1)     |     SL1759R has been referenced in 1 publications. [IF=38.138] Brestoff, Jonathan R., et al. "Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity." Nature (2014).  FCM ;  Human.   PubMed:25533952
Research Area	Neurobiology  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	ELISA=1:5000-10000 Flow-Cyt=1:100-500  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	0.5kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Met Enkephalin peptide (Tyr-Gly-Gly-Phe-Met)
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Enkephalin and enkephalin-like peptides have been detected in many animal species. In mammals these opioid pentapeptides are cleaved from a common precursor molecule which is expressed in a number of cell types, including neurons and endocrine cells associated with the sympathetic nervous system where they are often co-stored with catecholamines. They are known to be endogenous ligands for Sopioid receptors and are known to mediate analgesia at the spinal level. Met-enkephalin (tyr-gly-gly-phe-met) and leu-enkephalin (tyr-gly-gly-phe-leu) are pentapeptides which compete with and mimic the effects of opiate drugs. Although interest in enkephalins stems largely from their possible role in the brain, the richest source of these peptides is the adrenal gland. The amino acid sequence shows that the precursor is 267 amino acids long and contains 6 interspersed Met-enkephalin sequences and 1 Leu-enkephalin sequence. The precursor does not contain the sequences of dynorphin, alpha-neo-endorphin or beta-endorphin. (Because of structural similarities it had been postulated that beta-endorphin is precursor of Met-enkephalin, and that dynorphin or alpha-neo-endorphin is precursor of Leu-enkephalin.) Function: Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. Subcellular Location: Secreted. Post-translational modifications: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. Similarity: Belongs to the opioid neuropeptide precursor family. SWISS: P01210 Gene ID: 5179 Database links: Entrez Gene: 5179 Human Entrez Gene: 18619 Mouse Entrez Gene: 29237 Rat Omim: 131330 Human SwissProt: P01210 Human SwissProt: P22005 Mouse SwissProt: P04094 Rat Unigene: 339831 Human Unigene: 475097 Mouse Unigene: 10015 Rat

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