Product Name	P protein
Chinese Name	黑素细胞特异性Transporter抗体
Alias	BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2; EYCL3; eye color 2 (central brown); eye color 3 (brown); hair color 3 (brown); HCL3; Melanocyte-specific transporter protein; OCA2; oculocutaneous albinism II; oculocutaneous albinism II (pink-eye dilution homolog, mouse); P; P protein; P_HUMAN; PED; Pink eyed dilution protein homolog; Pink-eyed dilution protein homolog; SHEP1; total brown iris pigmentation.
Research Area	Tumour  Cell biology  Signal transduction  Cell type markers
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	93kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human P protein: 451-550/838 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes the human homologue of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine - a precursor of melanin. Mutations in this gene result in type 2 oculocutaneous albinism. [provided by RefSeq, Jul 2008] Function: Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Subcellular Location: Melanosome membrane. DISEASE: Defects in OCA2 are the cause of albinism oculocutaneous type 2 (OCA2) [MIM:203200]. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Although affected infants may appear at birth to have complete absence of melanin pigment, most patients acquire small amounts of pigment with age. Visual anomalies include decreased acuity and nystagmus. The phenotype is highly variable. The hair of affected individuals may turn darker with age, and pigmented nevi or freckles may be seen. African and African American individuals may have yellow hair and blue-gray or hazel irides. One phenotypic variant, 'brown OCA,' has been described in African and African American populations and is characterized by light brown hair and skin color and gray to tan irides. Similarity: Belongs to the CitM (TC 2.A.11) transporter family. SWISS: Q04671 Gene ID: 4948 Database links: Entrez Gene: 488683 Dog Entrez Gene: 100724327 Guinea pig Entrez Gene: 100034107 Horse Entrez Gene: 4948 Human Entrez Gene: 18431 Mouse Entrez Gene: 397171 Pig Entrez Gene: 24606 Rat Entrez Gene: 567419 Zebrafish Omim: 611409 Human SwissProt: Q04671 Human SwissProt: Q62052 Mouse SwissProt: Q8MIQ9 Pig Unigene: 654411 Human Unigene: 137052 Mouse

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