Product Name	OTOP1
Chinese Name	OTOP1蛋白抗体
Alias	A530025J20Rik; otop1; OTOP1_HUMAN; Otopetrin-1; Otp1; Tilted; tlt.
Research Area	Cell biology  Signal transduction  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	67kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human OTOP1: 321-420/612
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP. Subcellular Location: Membrane. Secreted > extracellular space. Detected in the gelatinous membrane overlying the inner ear macular epithelium. Similarity: Belongs to the otopetrin family. SWISS: Q7RTM1 Gene ID: 133060 Database links: Entrez Gene: 133060 Human Entrez Gene: 21906 Mouse Omim: 607806 Human SwissProt: Q7RTM1 Human SwissProt: Q80VM9 Mouse Unigene: 534544 Human

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