Product Name	Skuld
Chinese Name	Skuld蛋白抗体
Alias	CG9936-PC isoform C; Cg9936-pd isoform d; Jlkjlkj; MED13_DROME; Med13; Mediator complex subunit 13; Pap/DTRAP240; Protein blind spot; skd; Transcriptional coactivator blind spot; Trap240.
Research Area	Developmental biology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Fruit Fly,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	280kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Fruit fly Skuld: 601-700/2618
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Sklud is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Required for leg and eye development and macrochaete specification or differentiation. Negatively regulates sex comb development. Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for leg and eye development and macrochaete specification or differentiation. Negatively regulates sex comb development. Required for activated transcription of the MtnB and MtnD genes. Subunit: Component of the Cdk8 module of the Mediator complex, composed of CycC, Cdk8, kto and skd. Subcellular Location: Nuclear Similarity: Belongs to the Mediator complex subunit 13 family. SWISS: Q7KTX8 Gene ID: 43906 Database links: Entrez Gene: 43906 Fruit fly (Drosophila melanogaster) SwissProt: Q7KTX8 Fruit fly (Drosophila melanogaster)

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