Product Name	SKOR1
Chinese Name	SKOR1蛋白抗体
Alias	AV273001; C230094B15Rik; Corepressor for LBX1; CORL1; Functional smad suppressing element 15; Functional Smad suppressing element on chromosome 15; Functional Smad-suppressing element on chromosome 15; Fussel-15; FUSSEL15; Ladybird homeobox corepressor 1; Lbx1 corepressor 1; LBXCOR1; Lbxcor1 homolog; SKI family transcriptional corepressor 1; Skor1; SKOR1_HUMAN; Transcriptional corepressor CORL1.
Research Area	Developmental biology  Neurobiology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	100kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SKOR1: 1-100/965
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	LBXCOR1 is a 965 amino acid protein belonging to the SKI family. Localizing to nucleus, LBXCOR1 is highly expressed in the central nervous system (CNS) as well as developing spinal cord and adult brain and testis. LBXCOR1 contains a CH1 domain which is required for transcriptional repression and also acts as a transcriptional co-repressor of LBX1. LBXCOR1 additionally interacts with SMAD1, SMAD2 and SMAD3, and inhibits BMP signaling. Existing as three alternatively spliced isoforms, the gene encoding LBXCOR1 maps to human chromosome 15q23. Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and consists of about 3% of the human genome. Angelman and Prader-Willi syndromes, as well as Tay-Sachs disease and Marfan syndorme, are all associated with mutations to chromosome 15. Function: Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling. Subcellular Location: Nucleus. Tissue Specificity: Present specifically in cerebellar Purkinje cells (at protein level). Similarity: Belongs to the SKI family. SWISS: P84550 Gene ID: 390598 Database links: Entrez Gene: 207667 Mouse Entrez Gene: 315748 Rat SwissProt: Q8BX46 Mouse SwissProt: P84551 Rat Unigene: 36349 Mouse Unigene: 447200 Mouse Unigene: 58197 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SKOR1) Polyclonal Antibody, Unconjugated (SL17508R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SKOR1) Polyclonal Antibody, Unconjugated (SL17508R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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