Product Name	Dopamine D4 receptor
Chinese Name	多巴胺受体D4抗体
Alias	DRD4; DRD4 receptor; D4 dopamine receptor; DRD4_HUMAN.
literatures	Specific References  (1)     |     SL1746R has been referenced in 1 publications. [IF=4.181] Bai L et al. m6A demethylase FTO regulates dopaminergic neurotransmission deficits caused by arsenite.Toxicol Sci. 2018 Oct 1;165(2):431-446.  WB ;  Mouse.   PubMed:29982692
Research Area	Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41(mo/ rat); 51(kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DRD4: 151-250/467
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.DRD4 expression has been reported in various regions of the brain as well as in adrenal gland, artery, eye, heart, kidney, placenta, spinal cord, testis, and vas deferens. Function: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Subunit: Forms homo- and heterooligomers with DRD2. D4.7 allele exhibits higher affinity for homodimers compared to DRD2 heterodimers, while alleles D42. and 4.4 have similar affinities for both. The interaction with DRD2 may modulate agonist-induced downstream signaling. Interacts with CLIC6 (By similarity) and GPRASP1. May interact with ADORA2A. Interacts with KLHL12. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: Polyubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex: polyubiquitination does not lead to degradation of DRD4 protein. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P21917 Gene ID: 1815 Database links: Entrez Gene: 1815 Human Entrez Gene: 13491 Mouse Omim: 126452 Human SwissProt: P21917 Human SwissProt: P51436 Mouse Unigene: 99922 Human Unigene: 41075 Mouse
Product Picture	Sample: Hela(Human) Cell Lysate at 30 ug Urinary bladder (Mouse) Lysate at 40 ug Cerebrum (Mouse) Lysate at 40 ug Liver (Mouse) Lysate at 40 ug Primary: Anti- Dopamine D4 receptor (SL1746R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41/51 kD Observed band size: 51 kD Sample: A549(Human) Cell Lysate at 30 ug MKN45(Human) Cell Lysate at 30 ug Primary: Anti- Dopamine D4 receptor (SL1746R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 51 kD Observed band size: 53 kD Sample: Lane1: Brain(Mouse) Lysate at 30 ug Lane2: Liver(Mouse) Lysate at 30 ug Primary: Anti-DRD4(SL1746R) at 1:200 dilution; Secondary: HRP conjugated Goat Anti-Rabbit IgG(SL0295G-HRP) at 1: 3000 dilution; Predicted band size : 41kD Observed band size : 41kD

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