Product Name	HS3ST3A1
Chinese Name	HS3ST3A1蛋白抗体
Alias	3-OST-3A; 30ST3A1; 3OST3A1; h3 OST 3A; h3-OST-3A; heparan sulfate (glucosamine) 3 O sulfotransferase 3A1; Heparan sulfate 3 O sulfotransferase 3A1; Heparan sulfate 3-O-sulfotransferase 3A1; Heparan sulfate D glucosaminyl 3 O sulfotransferase 3A1; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1; Heparan sulfate glucosamine 3-O-sulfotransferase 3A1; HS3SA_HUMAN; HS3ST3A1.
Research Area	Cell biology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	45kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HS3ST3A1: 1-100/406 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [provided by RefSeq, Jul 2008] Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. Subcellular Location: Golgi apparatus membrane. Tissue Specificity: Ubiquitous. Most abundant in heart and placenta, followed by liver and kidney. Similarity: Belongs to the sulfotransferase 1 family. SWISS: Q9Y663 Gene ID: 9955 Database links: Entrez Gene: 9955 Human GenBank: NM_006042.1 Human Omim: 604057 Human SwissProt: Q9Y663 Human Unigene: 462270 Human

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