Product Name	CBX4
Chinese Name	染色盒同源物4抗体
Alias	CBX 4; CBX4_HUMAN; E3 SUMO-protein ligase CBX4; EC:2.3.2.-; Chromobox protein homolog 4; Polycomb 2 homolog (Pc2; hPc2); Pc2; hPc2;
literatures	Specific References  (3)     |     SL17376R has been referenced in 3 publications. [IF=4.658] Hu C et al. CBX4 promotes the proliferation and metastasis via regulating BMI‐1 in lung cancer. J Cell Mol Med. 2019 Nov 13.  WB&IHC-P ;  Human&Mouse.   PubMed:31724308 [IF=4.011] Xu J et al. Regulatory effect of two Trichinella spiralis serine protease inhibitors on the host's immune system. Sci Rep. 2019 Nov 19;9(1):17045.  WB ;  Mouse.   PubMed:31745105 [IF=1.91] Han, Xiao, et al. "HIF-1α SUMOylation affects the stability and transcriptional activity of HIF-1α in human lens epithelial cells." Graefe's Archive for Clinical and Experimental Ophthalmology 253.8 (2015): 1279-1290.  WB ;  Human.   PubMed:25877955
Research Area	Cell biology  Binding protein  Epigenetics  Ubiquitin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	61kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CBX4: 401-500/560
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Enables SUMO binding activity; SUMO ligase activity; and enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022] Function: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Subunit: Interacts with histone H3-K9Me3. Interacts with CHTOP (By similarity). Component of a PRC1-like complex. Self-associates. Interacts with SUV39H1 and HIPK2. Interacts with CSNK2B. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylated on Thr-497 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-494. Similarity: Contains 1 chromo domain. SWISS: O00257 Gene ID: 8535 Database links: Entrez Gene: 8535 Human Entrez Gene: 12418 Mouse Entrez Gene: 501403 Rat SwissProt: O00257 Human SwissProt: O55187 Mouse
Product Picture	Sample: Testis(Mouse) Cell Lysate at 40 ug Hepg2(Human) Cell Lysate at 30 ug Primary: Anti-CBX4 (SL17376R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 61 kD Observed band size: 62 kD Sample: Adrenal gland (Mouse) Lysate at 40 ug Jurkat(Human) Cell Lysate at 30 ug Testis (Mouse) Lysate at 40 ug HepG2(Human) Cell Lysate at 30 ug Primary: Anti- CBX4 (SL17376R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 61 kD Observed band size: 63 kD Sample: K562(Human) Cell Lysate at 30 ug MCF-7(Human) Cell Lysate at 30 ug Primary: Anti- CBX4 (SL17376R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 61 kD Observed band size: 61 kD

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