Product Name	HOXD12
Chinese Name	同源盒蛋白D12抗体
Alias	Homeobox protein Hox D12; Homeobox protein Hox-4H; Homeobox protein Hox-D12; Hox 4.7, mouse, homolog of; Hox 4H; HOX4H; HOXD12; HXD12_HUMAN.
Research Area	Cell biology  Binding protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	29kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HOXD12: 171-270/270
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The Hox (homeobox) genes play an important role in the development and design of anterior-posterior body axes in animals. Although Hox proteins can bind to DNA as monomers, dimerization with PBX homeoproteins can significantly increase the DNA binding activity of these transcription factors. The HoxD9 gene is involved in the development and patterning of the forelimb and axial skeleton. Transcriptional activation of HoxD9 has been shown to be enhanced by HMG1 (high mobility group protein 1) and antagonized by HoxD8, suggesting that Hox protein function depends on both DNA-protein and protein-protein interactions. The HOX genes are known to regulate a number of cell adhesion molecules (CAMs), with HoxD9 specifically increasing levels of L-CAM transcripts. In presomitic mesoderm, HoxD1 displays dynamic stripes of expression. In the three stages of diencephalon development, HoxD1 is strongly expressed in the first two stages and downregulated in the third stage. Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Subcellular Location: Nucleus. Similarity: Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain. SWISS: P35452 Gene ID: 3238 Database links: Entrez Gene: 3238 Human Entrez Gene: 15432 Mouse Entrez Gene: 366082 Rat Omim: 142988 Human SwissProt: P35452 Human SwissProt: P23812 Mouse Unigene: 450028 Human Unigene: 57124 Mouse
Product Picture	Sample: MCF-7(Human) Cell Lysate at 40 ug Primary: Anti-HOXD12 (SL17370R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 29 kD Observed band size: 22 kD Paraformaldehyde-fixed, paraffin embedded (Human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HOXD12) Polyclonal Antibody, Unconjugated (SL17370R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HOXD12) Polyclonal Antibody, Unconjugated (SL17370R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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