Product Name	hnRNP A0
Chinese Name	异质核糖核蛋白A0抗体
Alias	HNRNPA0; Heterogeneous nuclear ribonucleoprotein A0; hnRNA binding protein; hnRNP A0; HNRNPA0; ROA0_HUMAN.
Research Area	Cell biology  Binding protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	31kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human hnRNP A0: 1-100/305
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to mRNA transcription and pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. There are approximately 20 known hnRNP proteins and their complexes are the major constituents of the spliceosome. The majority of hnRNP protein components are localized to the nucleus; however, some shuttle between the nucleus and the cytoplasm. hnRNP I, also designated polypyrimidine tract-binding protein (PTB), and its homolog hnRNP L, bind to the 3' end of introns to modulate alternative splicing mechanisms of pre-mRNAs in normal cells and the translation of sev-eral viruses, including hepatitis C virus (HCV). The human hnRNP I gene maps to chromosome 19p13.3 and encodes a protein that is localized in the nucleoplasm. hnRNP L, like hnRNP I, is also localized in the nucleoplasm. Function: This protein is a component of ribonucleosomes. Subcellular Location: Nucleus. Component of ribonucleosomes. Post-translational modifications: Arg-291 is dimethylated, probably to asymmetric dimethylarginine. Similarity: Contains 2 RRM (RNA recognition motif) domains. SWISS: Q13151 Gene ID: 10949 Database links: Entrez Gene: 416302 Chicken Entrez Gene: 745876 Chimpanzee Entrez Gene: 540311 Cow Entrez Gene: 481524 Dog Entrez Gene: 10949 Human Entrez Gene: 77134 Mouse Entrez Gene: 498696 Rat Omim: 609409 Human SwissProt: Q13151 Human SwissProt: Q9CX86 Mouse Unigene: 645902 Human Unigene: 96996 Human Unigene: 490274 Mouse
Product Picture	Sample: Raw264.7(Mouse) Cell Lysate at 30 ug Primary: Anti-hnRNP A0 (SL17339R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 31 kD

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