Product Name	ODCp
Chinese Name	精氨酸脱羧酶抗体
Alias	L-Arginine decarboxylase; ADC; ADC_HUMAN; Antizyme inhibitor 2; ArgDC; Arginine decarboxylase; AZI2; KIAA1945; L-Arginine carboxy lyase; ODC antizyme inhibitor 2; ODC paralog; ODC-p; ODC-paralogue; ODC1L; ODCp; Ornithine decarboxylase like; Ornithine decarboxylase paralog; Ornithine decarboxylase-like protein.
Research Area	Cell biology  Neurobiology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	50kDa
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ODCp: 51-150/460
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ODCp is a 460 amino acid protein that is expressed in brain and testis. ODCp is a member of the Orn/Lys/Arg decarboxylase class-II family that catalyzes the creation of CO2 and agmatine from L-arginine. Mammalian ODCp differs from the forms expressed in bacteria and plants and shares less than 50% homology with Ornithine decarboxylase (ODC). ODCp is associated with the mitochondrial membrane where excess agmatine can be degraded by the enzyme Agmatinase or bound by the imidazoline recepto. In the brain, the highest levels of ODCp are found in the hypothalamus. Mammalian ODCp is thermally unstable and can be inhibited by Ca2+, Co2+ and polyamines. Function: Decarboxylates L-arginine to agmatine. Truncated splice isoforms probably lack activity. Subunit: Interacts with OAZ1, OAZ2 and OAZ3; the interactions stabilize the complex by inhibiting AZIN2 ubiquitination and degradation. Does not form an heterodimer with ODC1 (By similarity). Monomer. Interaction with OAZ1, OAZ2 and OAZ3; the interactions lead to increased ornithine decarboxylase (ODC)activity and decreased rate of ODC1 degradation. Subcellular Location: Nucleus. Tissue Specificity: Highly expressed in brain. Also expressed in testis. Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SWISS: Q96A70 Gene ID: 113451 Database links: Entrez Gene: 506961 Cow Entrez Gene: 478144 Dog Entrez Gene: 113451 Human Entrez Gene: 242669 Mouse Entrez Gene: 366473 Rat Omim: 608353 Human SwissProt: Q96A70 Human SwissProt: Q8BVM4 Mouse Unigene: 101807 Human Unigene: 215814 Mouse Unigene: 50921 Rat
Product Picture	Sample: Testis (Mouse)Lysate at 40 ug Primary: Anti-ODCp(SL16872R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 50kD Observed band size: 50kD Sample: Raji (Human)Cell Lysate at 40 ug Primary: Anti-ODCp(SL16872R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 50kD Observed band size: 50kD Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ODCp) Polyclonal Antibody, Unconjugated (SL16872R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructions and DAB staining.

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