Product Name	Cyclin F
Chinese Name	周期素F抗体
Alias	CCNF; F box only protein 1; FBX1; FBXO1; G2 mitotic specific cyclin F; CCNF_HUMAN.
Research Area	Cyclin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	86kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Cyclin F: 451-550/786
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Cyclin F belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Such proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. Subunit: Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Interacts with CCNB1; interaction is required for nuclear localization of CCNB1. Interacts with CCP110; this nteraction leads to CCP110 ubiquitination and degradation via the proteasome pathway. Subcellular Location: Nucleus. Cytoplasm, cytoskeleton, centrosome, centriole. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus. Tissue Specificity: Widely expressed. Post-translational modifications: Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence. Phosphorylated just before cells enter into mitosis. Similarity: Belongs to the cyclin family. Cyclin AB subfamily. Contains 1 cyclin N-terminal domain. Contains 1 F-box domain. SWISS: P41002 Gene ID: 899 Database links: Entrez Gene: 899 Human Entrez Gene: 12449 Mouse Omim: 600227 Human SwissProt: P41002 Human SwissProt: P51944 Mouse Unigene: 1973 Human Unigene: 77695 Mouse Cyclin F属于Fbxs蛋白亚型的一种，表达在不同的细胞增殖周期进程中,主要表达在G2-M。
Product Picture	Sample: U-2OS(Human) Cell Lysate at 30 ug Primary: Anti- Cyclin F (SL1686R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 86 kD Observed band size: 86 kD

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