Product Name	TRIM46
Chinese Name	TRIM46蛋白抗体
Alias	fibronectin type-III and C-terminal SPRY motif protein; Gene Y protein; GeneY; TRI46_HUMAN; TRIFIC; Trim46; Tripartite; Tripartite motif containing protein 46; Tripartite motif-containing protein 46; Tripartite, fibronectin type III and C terminal SPRY motif protein.
literatures	Specific References  (1)     |     SL16740R has been referenced in 1 publications. [IF=8.469] Tantai, Jicheng. et al. TRIM46 activates AKT/HK2 signaling by modifying PHLPP2 ubiquitylation to promote glycolysis and chemoresistance of lung cancer cells. Cell Death Dis. 2022 Mar;13(3):1-11  IHC ;  Human.   PubMed:35354796
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	83kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TRIM46: 401-500/759
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TRIM46 is a 759 amino acid intracellular protein that contains a variety of domains that are characteristic to TRIM proteins, including a RING-type zinc finger and a B box-type zinc finger. All subclass members, including TRIM46, TRIM9, TRIM67 and TRIM36, have conserved domain arrangement and associate with microtubule cytoskeleton, which may suggest that subcellular compartmentalization is determined by the unique domain architecture. The gene encoding TRIM46 is located on human chromosome 1, which spans about 260 million base pairs and comprises nearly 8% of the human genome. Similarity: Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 COS domain. Contains 1 fibronectin type-III domain. Contains 2 RING-type zinc fingers. SWISS: Q7Z4K8 Gene ID: 80128 Database links: Entrez Gene: 80128 Human Entrez Gene: 360213 Mouse Omim: 600986 Human SwissProt: Q7Z4K8 Human SwissProt: Q7TNM2 Mouse Unigene: 287735 Human Unigene: 331156 Mouse

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