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Product Name IPO11 Chinese Name RanBinding protein11抗体 Alias Imp11; Importin 11; Importin-11; IPO11; IPO11_HUMAN; Ran binding protein 11; Ran-binding protein 11; RanBP11; SLRN; Synleurin. Research Area Cell biology Chromatin and nuclear signals Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Horse, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 107kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human IPO11: 111-210/975 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]
Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12.
Subcellular Location:
Cytoplasm. Nucleus.
Similarity:
Belongs to the importin beta family.
Contains 15 HEAT repeats.
Contains 1 importin N-terminal domain.
SWISS:
Q9UI26
Gene ID:
51194
Database links:Entrez Gene: 51194 Human
Entrez Gene: 76582 Mouse
Omim: 610889 Human
SwissProt: Q9UI26 Human
SwissProt: Q8K2V6 Mouse
Unigene: 482269 Human
Unigene: 132208 Mouse
Unigene: 482687 Mouse
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