Product Name	Importin 13
Chinese Name	Importin 13蛋白抗体
Alias	Imp 13; Imp13; Importin-13; Importin13; IPO 13; IPO13; IPO13_HUMAN; Kap 13; Kap13; Karyopherin 13; Karyopherin-13; Karyopherin13; KIAA0274; Late gestation lung 2; Late gestation lung 2 protein; Lgl2; Ran binding protein 13; Ran-binding protein 13; RanBP 13; RanBP13
Research Area	Tumour  Cell biology  Signal transduction  Binding protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	108kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Importin 13: 51-150/963
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009] Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Expressed in fetal brain, heart, intestine and kidney. Similarity: Belongs to the importin beta family. Contains 14 HEAT repeats. Contains 1 importin N-terminal domain. SWISS: O94829 Gene ID: 9670 Database links: Entrez Gene: 9670 Human Entrez Gene: 523399 Cow Entrez Gene: 230673 Mouse Entrez Gene: 116458 Rat GenBank: NM_014652 Human Omim: 610411 Human SwissProt: A7YWD2 Cow SwissProt: O94829 Human SwissProt: Q8K0C1 Mouse SwissProt: Q9JM04 Rat Unigene: 158497 Human Unigene: 287810 Mouse Unigene: 14252 Rat
Product Picture	Sample: Muscle (Mouse) Lysate at 40 ug Primary: Anti-Importin 13 (SL16628R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 108 kD Observed band size: 100 kD

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