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Product Name SPPL2C Chinese Name 膜内蛋白酶5抗体 Alias IMP-5; IMP5; SPP2C_HUMAN; Intramembrane protease 5; Signal peptide peptidase-like 2C; SPP-like 2C; Research Area Cell biology Ubiquitin The cell membrane蛋白 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 72kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SPPL2C: 361-460/684 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Intramembrane proteolysis is now widely recognized as an important physiological pathway required for reverse signaling and membrane protein degradation. Aspartyl intramembrane cleaving proteases of the GXGD-type play an important regulatory role in health and disease. Signal peptide peptidase (SPP) and SPP-like (SPPL) peptidases, such as SPPL2a, SPPL2b, IMP5, and SPPL3, belong to the family of GXGD aspartic proteases. The putative catalytic domains of SPP and SPPLs are embedded in membranes in an orientation predisposed to cleave type II oriented transmembrane proteins. IMP5 (intramembrane protease 5), also known as SPPL2c (signal peptide peptidase-like 2C), is a 690 amino acid multi-pass membrane protein that may act as an intramembrane protease. IMP5 also belongs to the peptidase A22B family and two isoforms are produced by alternative splicing events.
Function:
May act as intramembrane protease.
Subcellular Location:
Membrane.
Similarity:
Belongs to the peptidase A22B family.
SWISS:
Q8IUH8
Gene ID:
162540
Database links:Entrez Gene: 162540 Human
Omim: 608284 Human
SwissProt: Q8IUH8 Human
Unigene: 144491 Human
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