Product Name	TRAPPC2
Chinese Name	SEDL蛋白抗体
Alias	hYP38334; MBP 1 interacting protein 2A; MBP-1-interacting protein 2A; MIP 2A; MIP-2A; MIP2A; SEDL; Sedlin; SEDLP; SEDT; Spondyloepiphyseal dysplasia tarda protein; Spondyloepiphyseal dysplasia, late; TPC2A_HUMAN; Trafficking protein particle complex 2; Trafficking protein particle complex subunit 2; TRAPPC2P1; TRS20; ZNF547L.
Research Area	Cell biology  Developmental biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	16kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TRAPPC2: 71-140/140
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010] Function: Prevents MBP1-mediated transcriptional repression and antagonizes MBP1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi. Subcellular Location: Cytoplasm > perinuclear region. Endoplasmic reticulum. Golgi apparatus. Localized in perinuclear granular structures. Tissue Specificity: Widely expressed. DISEASE: Defects in TRAPPC2 are the cause of spondyloepiphyseal dysplasia tarda (SEDT) [MIM:313400]. SEDT is an X-linked recessive disorder of endochondral bone formation. Similarity: Belongs to the TRAPP small subunits family. Sedlin subfamily. SWISS: O14582 Gene ID: 6399 Database links: Entrez Gene: 6399 Human Entrez Gene: 66050 Mouse Entrez Gene: 66226 Mouse Entrez Gene: 501550 Rat Omim: 300202 Human SwissProt: O14582 Human SwissProt: P0DI81 Human SwissProt: Q9CQP2 Mouse Unigene: 592238 Human Unigene: 622292 Human Unigene: 279752 Mouse Unigene: 35693 Mouse

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