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Product Name HSF5 Chinese Name 热休克因子蛋白5抗体 Alias FLJ40311; Heat shock factor protein 5; Heat shock transcription factor 5; Heat shock transcription factor family member 5; HSF 5; HSF5; HSF5_HUMAN; HSTF 5; MGC134827. Research Area Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 65kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HSF5: 1-100/596 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail HSF5 is a 596 amino acid protein that localizes to the nucleus and is thought to function as a transcription factor. Multiple isoforms of HSF5 exist due to alternative splicing events. The gene encoding HSF5 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Function:
May act as a transcriptional factor.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the HSF family.
SWISS:
Q4G112
Gene ID:
124535
Database links:Entrez Gene: 124535 Human
SwissProt: Q4G112 Human
Unigene: 380061 Human
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