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Product Name HSDL1 Chinese Name 类固醇脱氢酶样蛋白1抗体 Alias hsdl1; Hydroxysteroid dehydrogenase like protein 1; HSDL1_HUMAN; steroid dehydrogenase like. Research Area Tumour Cell biology Signal transduction The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 37kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HSDL1: 161-260/330 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail HSDL1 is a 330 amino acid protein that belongs to the short-chain dehydrogenases/reductases (SDR) family and 17-beta-HSD 3 subfamily. Localizing to the mitochondrion, HSDL1 is highly expressed in testis and ovary, with lower levels of expression found in thyroid, spinal cord, adrenal gland, heart, placenta, skeletal muscle, small intestine, colon, spleen, prostate and pancreas. HSDL1 interacts with DUSP24 and is encoded by a gene that maps to human chromosome 16q23.3 and mouse chromosome 8 E1. Chromosome 16 encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA, and is associated with a variety of genetic disorders. The rare disorder Rubinstein-Taybi syndrome is associated with chromosome 16 through the CREBBP gene, which encodes a critical CREB binding protein. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene.
Function:
Highly expressed in testis and ovary. Also detected in thyroid, spinal cord, adrenal gland, heart, placenta, skeletal muscle, small intestine, colon, spleen, prostate and pancreas.
Subcellular Location:
Mitochondrion.
Tissue Specificity:
Highly expressed in testis and ovary. Also detected in thyroid, spinal cord, adrenal gland, heart, placenta, skeletal muscle, small intestine, colon, spleen, prostate and pancreas.
Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
SWISS:
Q3SXM5
Gene ID:
83693
Database links:Entrez Gene: 83693 Human
Entrez Gene: 72552 Mouse
SwissProt: Q3SXM5 Human
SwissProt: Q8BTX9 Mouse
Unigene: 555992 Human
Unigene: 36756 Mouse
Unigene: 199069 Rat
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