Product Name	ZNF675
Chinese Name	Zinc finger protein675抗体
Alias	FLJ36350; TBZF; TIZ; TRAF6-binding zinc finger protein; TRAF6-inhibitory zinc finger protein; Zinc finger protein 675; ZN675_HUMAN; ZNF 675; ZNF675.
Research Area	transcriptional regulatory factor  Zinc finger protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	66kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ZNF675: 201-300/568
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. TBZF (TRAF6-inhibitory zinc finger protein), also known as Zinc finger protein 675, is a 568 amino acid nuclear protein that contains one KRAB domain and fifteen C2H2-type zinc fingers. Through modulation of TRAF6 signaling activity and inhibition of RANK signaling, TBZF may play a role in osteoclast differentiation. TBZF is regulated during differentiation of human peripheral blood monocytes into osteoclasts and transfection of TBZF into RAW264.7 cells reduces RANK ligand-induced osteoclastogenesis. Function: May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity. Subunit: Interacts with TRAF6. Subcellular Location: Nucleus (Probable). Similarity: Contains 15 C2H2-type zinc fingers. brContains 1 KRAB domain. SWISS: Q8TD23 Gene ID: 171392 Database links: Entrez Gene: 171392 Human SwissProt: Q8TD23 Human Unigene: 264345 Human

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