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Product Name GTF2A1 alpha Chinese Name 通用转录因子ⅡA亚基1/TFIIA-α抗体 Alias General transcription factor IIA subunit 1; General transcription factor IIA1; Glucose regulated protein 58kD pseudogene; gtf2a1; TF2A1; TF2AA_HUMAN; TFIIA 42; TFIIA alpha p55; TFIIA alpha p55, isoform 1; TFIIA p35 subunit; TFIIA-42; TFIIAL; Transcription initiation factor IIA alpha chain; Transcription initiation factor IIA subunit 1; Transcription initiation factor TFIIA 42 kDa subunit. Research Area Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 35/42kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GTF2A1 alpha: 1-100/376 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]
Function:
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.
Subcellular Location:
Nucleus.
Post-translational modifications:
The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteasomal degradation.
Similarity:
Belongs to the TFIIA subunit 1 family.
SWISS:
P52655
Gene ID:
2957
Database links:Entrez Gene: 2957 Human
Entrez Gene: 83602 Mouse
Omim: 600520 Human
SwissProt: P52655 Human
SwissProt: Q99PM3 Mouse
Unigene: 592334 Human
Unigene: 275728 Mouse
Unigene: 432242 Mouse
Unigene: 44436 Rat
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