Product Name	ZPBP2
Chinese Name	透明带Binding protein2抗体
Alias	MGC41930; Zona pellucida binding protein 2; Zona pellucida binding protein like; Zona pellucida-binding protein 2; ZPBP-like protein; Zpbp2; ZPBP2_HUMAN; ZPBPL.
Research Area	Cell biology  immunology  Developmental biology  Cell type markers
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ZPBP2: 51-150/338
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Mammalian gametes recognize each other when the plasma membrane of the sperm head binds to the zona pellucida (ZP), an extracellular coat surrounding eggs. The zona pellucida is composed of four major glycoproteins expressed in oocytes, ZP1, ZP2, ZP3 and ZP4. Important receptors of zona pellucida on sperm are the zona pellucida binding proteins (ZPBPs). ZPBPs are suggested to play an essential role in sperm-egg interaction. ZPBP2 (zona pellucida binding protein 2), also known as ZPBPL, is a 338 amino acid secreted protein that belongs to the zona pellucida-binding protein Sp38 family. Mutations in the gene encoding ZPBP2 may cause subfertility. ZPBP2 exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 17q12. Function: May be implicated in gamete interaction during fertilization. Subcellular Location: Secreted. Similarity: Belongs to the zona pellucida-binding protein Sp38 family. SWISS: Q6X784 Gene ID: 124626 Database links: Entrez Gene: 124626 Human SwissProt: Q6X784 Human Unigene: 367245 Human

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