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Product Name ZSCAN4 Chinese Name ZSCAN4蛋白抗体 Alias FLJ35105; MGC126787; MGC126789; Zinc finger and SCAN domain containing 4; Zinc finger and SCAN domain containing protein 4; Zinc finger and SCAN domain-containing protein 4; Zinc finger protein 494; ZNF 494; ZNF494; ZSCA4_HUMAN; ZSCAN4. Research Area Cell biology Transporter Zinc finger protein Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 49kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ZSCAN4: 331-433/433 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]
Function:
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells.
Subcellular Location:
Nucleus. Chromosome > telomere.
Similarity:
Contains 4 C2H2-type zinc fingers.
Contains 1 SCAN box domain.
SWISS:
Q8NAM6
Gene ID:
201516
Database links:Entrez Gene: 201516 Human
Omim: 613419 Human
SwissProt: Q8NAM6 Human
Unigene: 469663 Human
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