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Product Name FRZB/FRP-3 Chinese Name FRZB蛋白抗体 Alias FIZ; FRE; Frezzled; Fritz; Frizzled-related protein 1; FRP; FrzB 1; FRZB; MYOZ3_HUMAN; FRZB1; OTTMUSP00000014350; RP23-33L19.1; Secreted frizzled related protein 3 [Precursor]; Secreted frizzled related sequence protein 3; sFRP 3; SFRP. Research Area Cell biology Signal transduction Stem cells Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 27kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FRZB/FRP-3: 1-100/251 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
Function:
SFRP3/FRZB appears to be involved in limb skeletogenesis by regulating chondrocyte maturation and long bone development. Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. Antagonist of Wnt8 signaling.
Subcellular Location:
Secreted
Tissue Specificity:
Expressed specifically in skeletal muscle. Not detected in heart.
Similarity:
Belongs to the myozenin family.
SWISS:
Q92765
Gene ID:
2487
Database links:Entrez Gene: 2487 Human
Omim: 605083 Human
SwissProt: Q92765 Human
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