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Product Name FNBP4 Chinese Name FNBP4蛋白抗体 Alias DKFZp779I1064; FBP30; FNBP4_HUMAN; FLJ41904; FNBP 4; Formin binding protein 30; Formin binding protein 4; KIAA1014. Research Area Tumour Cell biology immunology Signal transduction Binding protein Cytoskeleton The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 110kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FNBP4: 921-1017/1017 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail FNBP4 is a 1,017 amino acid protein that contains two WW domains and binds to the Arg/Gly-rich-flanked Pro-rich domains of Formin 1, possibly regulating Formin 1 function. In response to DNA damage, FNBP4 is subject to post-translational phosphorylation, probably by ATM or ATR. The gene encoding FNBP4 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
Function:
FNBP4 (Formin binding protein 4) binds FMN1. It contains 2 WW domains which interact with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. Arginine methylation in these regions has no effect on this binding.
Similarity:
Contains 2 WW domains.
SWISS:
Q8N3X1
Gene ID:
23360
Database links:Entrez Gene: 23360 Human
Entrez Gene: 55935 Mouse
SwissProt: Q8N3X1 Human
SwissProt: Q6ZQ03 Mouse
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