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Rabbit Anti-FNBP4 antibody
Rabbit Anti-FNBP4 antibody
DKFZp779I1064; FBP30; FNBP4_HUMAN; FLJ41904; FNBP 4; Formin binding protein 30; Formin binding protein 4; KIAA1014.
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  • NO.:SL16156R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)
    Applications:ELISA IHC-P IHC-F ICC IF
    concentration:1mg/ml
  • Goods click count:28
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Details

Product Name FNBP4
Chinese Name FNBP4蛋白抗体
Alias DKFZp779I1064; FBP30; FNBP4_HUMAN; FLJ41904; FNBP 4; Formin binding protein 30; Formin binding protein 4; KIAA1014.  
Research Area Tumour  Cell biology  immunology  Signal transduction  Binding protein  Cytoskeleton  The new supersedes the old  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 110kDa
Cellular localization The nucleus 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human FNBP4: 921-1017/1017 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail FNBP4 is a 1,017 amino acid protein that contains two WW domains and binds to the Arg/Gly-rich-flanked Pro-rich domains of Formin 1, possibly regulating Formin 1 function. In response to DNA damage, FNBP4 is subject to post-translational phosphorylation, probably by ATM or ATR. The gene encoding FNBP4 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

Function:
FNBP4 (Formin binding protein 4) binds FMN1. It contains 2 WW domains which interact with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. Arginine methylation in these regions has no effect on this binding.

Similarity:
Contains 2 WW domains.

SWISS:
Q8N3X1

Gene ID:
23360

Database links:

Entrez Gene: 23360 Human

Entrez Gene: 55935 Mouse

Entrez Gene: 311183 Rat

SwissProt: Q8N3X1 Human

SwissProt: Q6ZQ03 Mouse



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