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Product Name FMO2 Chinese Name 肝黄素单加氧酶2抗体 Alias 2310008D08Rik; 2310042I22Rik; AW107733; Dimethylaniline monooxygenase [N oxide forming] 2; Dimethylaniline monooxygenase [N-oxide-forming] 2; Dimethylaniline oxidase 2; Flavin containing monooxygenase 2 (non functional); Flavin containing monooxygenase 2; FLJ40826; FMO 1B1; FMO 2; FMO; FMO pulmonary; FMO1B1; FMO2; FMO2_HUMAN; MGC28212; OTTMUSP00000028686; OTTMUSP00000028687; Pulmonary flavin containing monooxygenase 2; Pulmonary flavin-containing monooxygenase 2. Research Area Cell biology immunology Signal transduction The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, Chimpanzee, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 53kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FMO2: 51-150/471 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, in some human populations, this enzyme is truncated and likely degraded rapidly. The protein encoded by this gene represents the truncated form and apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1. [provided by RefSeq, Jun 2013]
Function:
Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive.
Subcellular Location:
Microsome membrane. Endoplasmic reticulum membrane.
Tissue Specificity:
Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain.
Post-translational modifications:
The truncated form is probably unable to fold correctly and is rapidly degraded. FMO2*1 is sumoylated at 'Lys-492'.
Similarity:
Belongs to the FMO family.
SWISS:
Q99518
Gene ID:
2327
Database links:Entrez Gene: 2327 Human
Entrez Gene: 55990 Mouse
Entrez Gene: 100171693 Orangutan
Entrez Gene: 703639 Rhesus monkey
Omim: 603955 Human
SwissProt: Q8HZ70 Chimpanzee
SwissProt: Q8HZ69 Gorilla
SwissProt: P36366 Guinea pig
SwissProt: Q99518 Human
SwissProt: Q8K2I3 Mouse
SwissProt: Q5REK0 Orangutan
SwissProt: Q28505 Rhesus monkey
Unigene: 144912 Human
Unigene: 10929 Mouse
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