Product Name	FLYWCH1
Chinese Name	FLYWCH1蛋白抗体
Alias	DKFZp761A132; FWCH1_HUMAN; FLYWCH type zinc finger containing protein 1; FLYWCH zinc finger 1; FLYWCH-type zinc finger 1; KIAA1552.
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	90kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FLYWCH1: 631-715/715
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	FLYWCH1 (FLYWCH-type zinc finger 1) is a 716 amino acid nuclear protein containing five FLYWCH-type zinc fingers. Existing as five alternatively spliced isoforms, FLYWCH1 is encoded by a gene located on human chromosome 16p13.3. Chromosome 16 encodes over 900 genes and comprises nearly 3% of human cellular DNA. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16 through the CREBBP gene, which encodes a critical CREB binding protein. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier. Function: FLYWCH, also commonly known as FLYWCH-type zinc finger 1, is a nuclear DNA-binding protein. It contains 5 FLYWCH-type zinc finger domains and is 716 amino acids in length. There are five isoforms of the protein produced by alternative splicing. Isoform 1 (80 kDa) is the canonical form. Subcellular Location: Nuclear Similarity: ontains 5 FLYWCH-type zinc fingers. SWISS: Q4VC44 Gene ID: 84256 Database links: Entrez Gene: 84256 Human SwissProt: Q4VC44 Human

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