Product Name	RFIP3
Chinese Name	Rab11-FIP3蛋白抗体
Alias	EF hands containing Rab interacting protein; Eferin; RFIP3_HUMAN; Rab11 family interacting protein 3; RAB11FIP3; RFIP3.
Research Area	Cell biology  immunology  Signal transduction  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	82kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FIP3: 651-756/756
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008] Function: FIP3 (RAB11FIP3) is one of many proteins that interact with and regulate Rab GTPases. Forms an heterooligomeric complex with RAB11FIP4. Binds to RAB11A, RAB11B and RAB25. Subunit: Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Interacts with RAB11B, RAB25 and RAB11FIP4. Interacts with ARF6; according to PubMed:16148947, it specifically interacts with ARF6 but not ARF5. Interacts with ARF6; according to PubMed:17030804 but not PubMed:16148947. Interacts with RACGAP1/MgcRacGAP; interaction takes place during late stage of cytokinesis and is required for recruitment to the midbody. Interacts with ASAP1 and EXOC7. Subcellular Location: Recycling endosome membrane; Peripheral membrane protein. Cytoplasm; cytoskeleton; centrosome. Cleavage furrow. Midbody. Post-translational modifications: Phosphorylated at Ser-102 by CDK1 during metaphase, and dephosphorylated as cells enter telophase. Similarity: Contains 2 EF-hand domains. Contains 1 FIP-RBD domain. SWISS: O75154 Gene ID: 9727 Database links: Entrez Gene: 9727 Human Entrez Gene: 303002 Rat Omim: 608738 Human SwissProt: O75154 Human
Product Picture	Sample: U937(Human) Cell Lysate at 30 ug Primary: Anti-RFIP3 (SL16089R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 82 kD Observed band size: 82 kD

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