Product Name	FGD3
Chinese Name	FGD3蛋白抗体
Alias	Faciogenital dysplasia 3; FGD1 family, member 3; FGD3; FGD3_HUMAN; FYVE; FYVE, RhoGEF and PH domain containing 3; FYVE, RhoGEF and PH domain containing protein 3; RhoGEF and PH domain-containing protein 3; ZFYVE5; Zinc finger FYVE domain containing protein 5; Zinc finger FYVE domain-containing protein 5.
Research Area	Cell biology  Signal transduction  The cell membrane受体  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	79kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FGD3: 501-600/725
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	FGD1 gene mutations result in faciogenital dysplasia (FGDY, Aarskog-Scott syndrome), an X-linked developmental disorder that adversely affects the formation of multiple skeletal structures. FGD1 maps to human chromosome Xp11.21 and shares a high degree of sequence identity with the FGD2 (6p21.2) and the FGD3 (9q22.31) proteins. FGD1 encodes a guanine nucleotide exchange factor that specifically activates the Rho GTPase Cdc42. FGD2 is present in several diverse tissues during embryogenesis, suggesting a role in embryonic development. FGD3 stimulates fibroblasts to form filopodia, which are Actin microspikes formed upon the stimulation of Cdc42. All FGD family members contain equivalent signaling domains and a conserved structural organization, which strongly suggests that these signaling domains form a canonical core structure for members of the FGD family of RhoGEF proteins. These proteins control essential signals required during embryonic development. Function: Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Subcellular Location: Cytoplasm. Cytoplasm > cytoskeleton. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 FYVE-type zinc finger. Contains 2 PH domains. SWISS: Q5JSP0 Gene ID: 89846 Database links: Entrez Gene: 89846 Human Entrez Gene: 30938 Mouse Entrez Gene: 361223 Rat SwissProt: Q5JSP0 Human SwissProt: O88842 Mouse Unigene: 411081 Human Unigene: 291089 Mouse Unigene: 214480 Rat
Product Picture	Sample: 293T Cell (Human) Lysate at 40 ug Primary: Anti-FGD3 (SL16079R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 79 kD Observed band size: 75 kD

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