Product Name	FCF1
Chinese Name	FCF1蛋白抗体
Alias	Bka; C14orf111; CGI 35; Fcf1; FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); FCF1_HUMAN; rRNA processing protein FCF1 homolog; rRNA-processing protein FCF1 homolog.
Research Area	Cell biology  Transporter  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FCF1: 1-100/198
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Ribosomes are the organelles that catalyze protein synthesis. Ribosomes consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. FCF1 is a 198 amino acid protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. The gene encoding FCF1 maps to human chromosome 14, which contains about 700 genes and makes up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder α1-antitrypsin deficiency. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14;19) translocations found in a variety of B cell malignancies. Function: Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Subcellular Location: Nucleus > nucleolus. Similarity: Belongs to the UTP23/FCF1 family. FCF1 subfamily. Contains 1 PINc domain. SWISS: Q9Y324 Gene ID: 51077 Database links: Entrez Gene: 51077 Human Entrez Gene: 100507758 Human SwissProt: Q9Y324 Human Unigene: 579828 Human Unigene: 711584 Human

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