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Product Name FbxL7 Chinese Name FbxL7蛋白抗体 Alias AL023057; D230018M15Rik; F Box and Leucine Rich Repeat Protein 7; F box protein FBL6/FBL7; F box/LRR-repeat protein 7; F-box and leucine-rich repeat protein 7; F-box protein FBL6/FBL7; F-box/LRR-repeat protein 7; FBL 6; FBL 7; FBL6; FBL7; FBXL 7; FBXL7; FBXL7_HUMAN; FLJ11609; KIAA0840; MGC102204. Research Area Cell biology Signal transduction Stem cells Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 55kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FbxL7: 1-100/491 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Function:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Similarity:
Contains 1 F-box domain. Contains 11 LRR (leucine-rich) repeats.
SWISS:
Q9UJT9
Gene ID:
23194
Database links:Entrez Gene: 23194 Human
Entrez Gene: 448987 Mouse
Omim: 605656 Human
SwissProt: Q9UJT9 Human
SwissProt: Q5BJ29 Mouse
Unigene: 433057 Human
Unigene: 76798 Human
Unigene: 253378 Mouse
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